Expression of cyclooxygenase-2 and vascular endothelial growth factor in human prostate cancer and its significance.
- Author:
Tie-xiong JIN
1
;
Xiao-gang LI
;
Wen-yuan WU
;
Dong-ming PIAO
;
Jing-yan FENG
;
Jing SANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Cyclooxygenase 2; biosynthesis; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Prognosis; Prostatic Hyperplasia; metabolism; pathology; Prostatic Neoplasms; metabolism; pathology; Vascular Endothelial Growth Factor A; biosynthesis
- From: National Journal of Andrology 2006;12(3):207-210
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate expressions of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in primary prostate cancer and its clinical significance.
METHODSExpressions of COX-2 and VEGF were detected by immunohistochemical assay in tissues of 40 prostate cancer and 10 benign prostatic hyperplasia samples.
RESULTSCOX-2 and VEGF levels in prostate cancer were much higher than those in BPH. The degrees of cancer malignancy and invasion positively correlated with the expressions of COX-2 and VEGF. COX-2 level positively correlated with VEGF level.
CONCLUSIONThe abnormal expression of COX-2 plays an important role in the development of primary prostate cancer. COX-2 and VEGF are good molecular markers of prostate cancer which are hopeful to be used for the assistant diagnosis and the prediction of prognosis of prostate cancer.
