Effects of senility on inducible nitric oxide synthase expression and cell apoptosis in rat penis.
- Author:
Bo LIU
1
;
Ji-hong LIU
;
Tao WANG
;
Heng-jun XIAO
;
Jun CHEN
;
Dong-xi LUO
;
Zhang-qun YE
Author Information
- Publication Type:Journal Article
- MeSH: Aging; metabolism; pathology; Animals; Apoptosis; In Situ Nick-End Labeling; Male; Nitric Oxide Synthase Type II; biosynthesis; Penis; metabolism; pathology; Random Allocation; Rats; Rats, Wistar
- From: National Journal of Andrology 2006;12(3):251-257
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo investigate the effect of senility on inducible nitric oxide synthase (iNOS) expression and apoptosis in rat penis.
METHODSThe rats were divided into three groups randomly: senescent, aged and young. Their penises were harvested to detect iNOS expression by immunohistochemistry and cell apoptosis rate by TUNEL, respectively.
RESULTSiNOS expression were 0.24 +/- 0.03, 0.17 +/- 0.02, 0.12 +/- 0.03 (relative A) and cell apoptosis rate were (1.41 +/- 0.78)%, (0.94 +/- 0.43)% and (0.50 +/- 0.23 )%, respectively, in the tissues of three groups. The differences among three groups were considerable significance (P <0.05).
CONCLUSIONIt maybe one of the mechanisms of erectile dysfunction in the aging male that senility causes the increase of iNOS expression and cell apoptosis.
