Advances in xenogeneic transplantation of spermatogonial stem cell and its bewilderment in clinical application.
- Author:
Liang-hong MA
1
;
Qiang DING
;
Xiang WANG
Author Information
1. Department of Urology, Huashan Hospital, Shanghai Medical College, Fudan University, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Transplantation;
methods;
Humans;
Male;
Mice;
Rats;
Seminiferous Tubules;
Spermatogonia;
transplantation;
Stem Cell Transplantation;
Transplantation, Homologous
- From:National Journal of Andrology
2006;12(3):258-262
- CountryChina
- Language:Chinese
-
Abstract:
Results from the transplantation of donor spermatogonia into xenogeneic recipient seminiferous tubules indicate that donor germ cells are capable of differentiating to form spermatozoa with morphological character of the donor species. With the advances in freezing, culturing in vitro and enriching germ cell populations, germ cell transplantation procedures have applications of paramount values in medicine, basic science and animal reproduction. Additionally, these techniques can serve as an alternative approach for gonadal protection and fertility preservation especially in patients accepting large dose of chemotherapy or radiotherapy. In this article we reviewed the recent advances in xenogeneic transplantation of spermatogonial stem cell and also analyzed the potential problems existing in its clinical application.
