Detection of peripheral blood Th1/Th2 cell ratio in patients with chronic abacterial prostatitis/chronic pelvic pain syndrome.
- Author:
Hai-hong LIU
1
;
Xin-yi XIA
;
Yong-ming WU
;
Lian-jun PAN
;
Bao-fang JIN
;
Xue-jun SHANG
;
Yu-feng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Chronic Disease; Flow Cytometry; Humans; Interferon-gamma; blood; Interleukin-4; blood; Male; Middle Aged; Pelvic Pain; immunology; Prostatitis; immunology; Th1 Cells; immunology; Th2 Cells; immunology
- From: National Journal of Andrology 2006;12(4):330-336
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the change of peripheral Th1/Th2 cells in patients with CAP/CPPS and its significance in various clinical types of CAP/CPPS.
METHODSInterferon-gamma (IFN-gamma) and interleukin-4 (IL-4) secreted by CD3+ CD8(-)T cells were detected by flow cytometry in 35 patients with CAP/CPPS and 12 healthy volunteers, and significance of Th1/Th2 cells ratio in the etiology of CAP/CPPS was analyzed.
RESULTSCompared with control group, peripheral Th1 cells were significantly increased in patients with IIIA and III B CAP/CPPS, the Th1/Th2 cell ratio was apparently increased (P <0.05), while Th2 cells was not different from that in the control(P>0.05 ); Th1, Th2 cells and Th1/Th2 in patients with IIIA CPPS were not statistically different from those in III B CPPS respectively (P > 0.05) .
CONCLUSIONThere is a Th1/Th2 imbalance in CAP/CPPS patients with an increase of Th1 type cytokines. Th1 cell may play an important role in the pathogenesis of CAP/CPPS.
