Expression and significance of survivin protein, PTEN in prostatic cancer.
- Author:
Xue-yan XIA
1
;
Lian-hong LI
;
Xian-cheng LI
;
Tao JANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Male; Microtubule-Associated Proteins; biosynthesis; Middle Aged; Neoplasm Proteins; biosynthesis; PTEN Phosphohydrolase; biosynthesis; Prognosis; Prostatic Neoplasms; metabolism; pathology
- From:National Journal of Andrology 2006;12(4):346-351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expressions of survivin, PTEN and their relationships with tissue grade and pathology stage in prostatic carcinoma (PCa).
METHODSThe immunohistological staining was used to evaluated the expressions of survivin protein and PTEN in 43 case of prostatic carcinoma (PCa) and 5 cases of benign prostatic hyperplasia (BPH).
RESULTSThe positive rate of survivin protein was 81.40%. Expression of survivin protein in 5 case of BPH was negative. The positive rate of PTEN was 30.23%, and the higher the grade and the clinical stage of tumors were, the lower the expression of PTEN was, PTEN of 5 case of BPH was positive.
CONCLUSIONThe positively correlation was found between the abnormal expressions of survivin protein, PTEN and the biological behavior of prostatic carcinoma (PCa). Detection of survivin combined with PTEN is valuable for diagnosing PCa, and evaluating malignancy extent and prognosis.
