Progress of regulation of leukemia stem cells of chronic myeloid leukemia by autophagy.
10.19540/j.cnki.cjcmm.20171010.002
- Author:
Ling-Yan ZHU
1
;
Wei-Hong GE
1
;
Yu-Qing GE
2
;
Guang-Ji ZHANG
1
;
Ru-Bin CHENG
1
Author Information
1. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
2. The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310006, China.
- Publication Type:Journal Article
- Keywords:
autophagy;
chemosensitivity;
chronic myeloid leukemia;
leukemia stem cells;
research progress
- From:
China Journal of Chinese Materia Medica
2017;42(23):4542-4547
- CountryChina
- Language:Chinese
-
Abstract:
Leukemia stem cells (LSC) that were found in chronic myeloid leukemia (CML) responsible for the abnormal proliferation with the potential of self-renewal and multi-directional differentiation are involved in the pathophysiological process for drug resistance and relapse of CML. Autophagy, a conservative lysosomal degradation process that mediates cell degradation and recycling process, plays crucial roles in maintaining the homeostasis and function of intracellular environment. Recent studies suggested that autophagy is involved in the regulation of LSC differentiation and also closely related to the chemo-sensitivity of CML. In this review, we focused on the role of autophagy on chemotherapy sensitivity of CML as well as the leukemia stem cell function for the development of new anti-leukemia drugs.
