A new sesquiterpene from Chinese agarwood induced by artificial holing.
10.19540/j.cnki.cjcmm.2017.0202
- Author:
Tong-Dong KUANG
1
;
Hui-Qin CHEN
2
;
Wei LI
2
;
Jin-Ling YANG
2
;
Li-Man ZHOU
2
;
Cai-Hong CAI
2
;
Wen-Hua DONG
2
;
Wen-Li MEI
2
;
Hao-Fu DAI
2
Author Information
1. Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
2. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
- Publication Type:Journal Article
- Keywords:
agarwood;
biological activity;
n-butanol extract;
sesquiterpene
- From:
China Journal of Chinese Materia Medica
2017;42(23):4618-4623
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the chemical constituents of n-butanol fraction of ethanol extract from Chinese agarwood induced by artificial holing, various chromatographic techniques were carried out to isolate compounds, and the structures of compounds were determined through a combined analysis of physicochemical properties and spectroscopic evidence. Seven compounds were obtained and identified as selina-3,11-dien-9,15-diol (1), aquilarone D (2), 5α,6β,7α,8β-tetrahydroxy-2-[2-(2-hydroxyphenyl)ethyl]-5,6,7,8-tetrahydrochromone (3), 6,7-dimethoxy-2-[2-(4-methoxyphenyl)ethyl]chromone (4), syringin (5), methyl (Z)-p-coumarate (6), and 4'-methoxycinnamic acid (7), among which compound 1 was a new compound and compounds 5-7 were isolated from agarwood for the first time. The bioactivity assay results concluded that compounds 6 and 7 showed certain nematicidal activity against Panagrellus redivivus, and compounds 4, 6 and 7 exhibited cytotoxicity against BEL-7402, SGC-7901 and A549 carcinoma cell lines.
