Effects of ginkgolide A, B and K on platelet aggregation.
10.19540/j.cnki.cjcmm.2017.0207
- Author:
Kui-Long WANG
1
;
Zhuo-Qiong LI
1
;
Ze-Yu CAO
1
;
Zhi-Peng KE
1
;
Liang CAO
1
;
Zhen-Zhong WANG
1
;
Wei XIAO
1
Author Information
1. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China.
- Publication Type:Journal Article
- Keywords:
ginkgolide A;
ginkgolide B;
ginkgolide K;
platelet activating factor (PAF);
platelet aggregation
- From:
China Journal of Chinese Materia Medica
2017;42(24):4722-4726
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of ginkgolide A (GA), ginkgolide B (GB) and ginkgolide K (GK) on platelet aggregation in rabbits, and compare the similarities and differences among these three components. The effects of different doses of ginkgolide A, B and K on platelet aggregation induced by platelet activating factor (PAF) were observed by using in vitro experiment. The results showed that three compounds could inhibit platelet aggregation induced by PAF in vitro, and the intensity was GK> GB> GA. It was further found that all of them can mobilize [Ca2+]i and enhance intracellular c-AMP level in a dose-dependent manner, which was consistent to the ability to antagonize PAF receptor. These findings indicated that GK was highly selective for PAF receptor, and may inhibit platelet aggregation by activating cAMP signaling pathway and inhibiting intracellular [Ca2+]i mobilization; GB and GA also had strong antagonism to PAF receptor, but the effect was weaker than that of GK.
