Significance of changes in plasma bactericidal/permeability-increasing protein levels in patients with severe surgical infection.
- Author:
Li-tian ZHANG
1
;
Yong-ming YAO
;
Jia-qi LU
;
Yan YU
Author Information
- Publication Type:Journal Article
- MeSH: Acute-Phase Proteins; Adolescent; Adult; Antimicrobial Cationic Peptides; blood; Blood Proteins; Carrier Proteins; blood; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-6; blood; Male; Membrane Glycoproteins; blood; Middle Aged; Postoperative Complications; blood; microbiology; Prognosis; Prospective Studies; Sepsis; blood
- From: Chinese Journal of Surgery 2007;45(19):1342-1345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate changes in endogenous bactericidal/permeability-increasing protein (BPI) levels and their significance in patients with surgical sepsis.
METHODSIn the prospective study, 19 surgical patients with infection were involved. The plasma BPI, lipopolysaccharide-binding protein (LBP) and interleukin-6 levels were measured on post-infected days 1, 3, 5, 7 and 14 by an enzyme-linked immunosorbent assay (ELISA). Plasma endotoxin concentrations were determined by the modified chromogenic Limulus Amebocyte Lysate (LAL).
RESULTSCompared with normal controls, significant lower plasma BPI/LBP ratios were observed in septic patients on days 1 to 5 after infection (P < 0.01), and in severe septic patients on days 1 to 7 (P < 0.01). Moreover, plasma BPI/LBP ratios were much lower in severe sepsis than those in sepsis on days 1 to 3 after infection (P < 0.05).
CONCLUSIONSPlasma BPI and LBP levels increased rapidly after infection, but BPI/LBP ratios were significantly decreased during sepsis. Plasma BPI/LBP ratios appear to be closely related to the severity of sepsis in patients complicated by surgical infection.
