Influence of intrahepatic cholestasis during pregnancy on the incidence of preterm birth
10.3760/cma.j.issn.0254-6450.2017.10.024
- VernacularTitle:妊娠期肝内胆汁淤积症对早产发生率的影响
- Author:
Maimaiti REYIHANGULI
1
,
2
;
Haiyan LIU
;
Wenhui HAN
;
Yefei LUO
;
Anqun HU
;
Yan WANG
;
Haili WANG
;
Haiyan XIONG
;
Yingjie ZHENG
Author Information
1. 200032 上海,复旦大学公共卫生学院卫生微生物学教研室
2. 200032 上海,复旦大学公共卫生学院流行病学教研室
- Keywords:
Intrahepatic cholestasis of pregnancy;
Preterm birth;
Cohort study
- From:
Chinese Journal of Epidemiology
2017;38(10):1415-1418
- CountryChina
- Language:Chinese
-
Abstract:
Objective Intrahepatic cholestasis during pregnancy (ICP) and its relation to incidence of preterm birth (PTB) were under study.Methods A prospective cohort study was carried out that including all the hospitalized pregnant women with live singleton births,from January 2014 to March 2015 in Anqing Municipal Hospitals.Informed consent was followed in every pregnant woman with related demographic information collected through questionnaire and hospital electronic medical record system.Both univariate and multi-variate statistical methods were used to analyze the relations between ICP and incidence of PTB.Results A total of 2 758 pregnant women were included in this study.The incidence proportions of ICP and PTB appeared as 7.25％ and 16.28％ respectively.Results from the logistic regression analysis showed that ICP increased the risk of both overall PTB (RR=2.33,95％CI:1.67-3.25) and medically indicated PTB (RR=8.46,95％CI:5.45-13.12),but not the spontaneous PTB (RR=0.94,95％CI:0.57-1.54).Conclusion ICP seemed to have increased the risk on medically indicated PTB but not the spontaneous PTB.
