Current state of studies on screening method for sensitinogens in injections for traditional Chinese medicine and synthetic immunity method.
- Author:
Fu-yuan HE
1
;
Kai-wen DENG
;
Jiao-li ZENG
;
Ru-wen DAI
;
Zan-shao XIA
;
Weng-long LIU
;
Ji-lian SHI
Author Information
1. Department of Pharmaceutics, Hu'nan University of Chinese Medicine, Changsha 410208, China. pharmsharking@tom.com
- Publication Type:Journal Article
- MeSH:
Drug Hypersensitivity;
immunology;
Drugs, Chinese Herbal;
administration & dosage;
adverse effects;
chemistry;
toxicity;
Humans;
Medicine, Chinese Traditional;
methods
- From:
China Journal of Chinese Materia Medica
2012;37(19):2836-2841
- CountryChina
- Language:Chinese
-
Abstract:
Injections for traditional Chinese medicine have over 60 years of history of development and application. In recent years, however, their adverse reactions have been reported one after another. Consequently, studies on screening sensitinogens (sensibiligens) from injections for traditional Chinese medicine have drawn people's attention and become a tough problem all over the world. This essay analyzes the current state of studies on screening techniques of sensitinogens in injections for traditional Chinese medicine according their mechanism of immunotoxicity, and then proposes to adopt the synthetic immunoassay combining immunity bottle chip, immunity cover chip and immunity chromatographic fingerprint to screen sensitinogens from injections for traditional Chinese medicine, in order to build a safety evaluation barrier for development and clinical application of injections for traditional Chinese medicine.
