Drug releasing characteristics evaluation to multi-drug delivery system of tongmai pellets.
- Author:
Dan-hong YU
1
;
Yang HUANG
;
Xiao-bin JIA
;
Jing ZHU
;
Dan LIU
;
Wei XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Dosage Forms; Drug Delivery Systems; Medicine, Chinese Traditional; Pharmaceutical Preparations; administration & dosage; chemistry
- From: China Journal of Chinese Materia Medica 2012;37(19):2889-2893
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish the drug release method of multi-drug delivery system of tongmai pellets.
METHODThe drug releasing characteristics were researched by HPLC and UV spectrophotometric method. The drug releasing characteristics of the multi-drug delivery system of tongmai pellets between single unit and multiple drug delivery system were evaluated by HPLC.
RESULTThe four pellets release unit isoflavones pellets, tanshinone pellets, Sal pellets, chuanxiong acid by ultraviolet spectrophotometry and HPLC method of dissolution obtained similar curves, and the similarity factor f2 were 63.31, 81.59, 70.93, 68.08. The release unit after the formation of multiple drug delivery system had no influence on single unit.
CONCLUSIONInitial construction of multiple drug delivery system tongmai pellets improved the dissolution of insoluble components, the overall performance of the combination of rapid release and sustained release characteristics, in line with the design requirements.
