OBJECTIVETo explore safety evaluation information about Kudiezi injection used in the clinical practice.

METHODThree Chinese literature databases were searched and 96 articles were downloaded. Safety information about the study question was extracted by researchers in the Excel form. Finally, 22 articles including 24 case reports were analyzed in this article. Five aspects about safety information were summarized.

RESULTIt was found that all the adverse drug reaction reports in the literature were improper. There was no clear causality relation inference. It was inaccurate that those reports were identified as adverse drug reactions.

CONCLUSIONAlthough 24 case reports were identified as adverse drug reaction the evidence for each report was insufficient. There is no scientific causality judgment among these reports, which were implied little significance to future health decision about Kudiezi injection.