Progress on cardiovascular protections and mechanism research of puerarin.
- Author:
Shu-yong WEI
- Publication Type:Journal Article
- MeSH:
Animals;
Cardiovascular Diseases;
genetics;
metabolism;
prevention & control;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Isoflavones;
pharmacology;
Oxidative Stress;
drug effects;
Protective Agents;
pharmacology;
Pueraria;
chemistry;
Signal Transduction;
drug effects
- From:
China Journal of Chinese Materia Medica
2015;40(12):2278-2284
- CountryChina
- Language:Chinese
-
Abstract:
Puerarin is one of the most important effective components of Pueraria lobata which exhibited classic estrogen-like biological activities and had remarkable cardiovascular protections in vivo and in vitro experiments. These protections of puerarin are mainly exhibited on improving the myocardial cells membrane potential and arrhythmia based on effecting the Na+, K+ , and Ca2+ channels,resisting myocardial fibrosis damage, diastolic effect on blood vessels, promoting angiogenesis, resisting calcification and atherosclerosis, improving blood flow, antiplatelet aggregation, reducing lipid and resisting diabetes. The main mechanisms are to improve the membrane potential and reduce cardiovascular damage caused by inflammation, oxidative stress and apoptosis, and the main regulated signal pathways are the PI3K/Akt, the NF-kappa B and the caspases.
