A Case of Isolated Light Chain Deposition Disease in the Duodenum.
10.3346/jkms.2012.27.2.207
- Author:
Hee Jun KIM
1
;
Eunkyung PARK
;
Tae Jin LEE
;
Jae Hyuk DO
;
Young Joo CHA
;
Sang Jae LEE
Author Information
1. Division of Hemato-Oncology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. epark@cau.ac.kr
- Publication Type:Case Reports
- Keywords:
Light Chain Deposition Disease (LCDD);
Duodenal Polyp;
Isolated LCDD
- MeSH:
Duodenum/pathology;
Endoscopy, Gastrointestinal;
Humans;
Immunoglobulin kappa-Chains/*immunology/metabolism;
Immunohistochemistry;
Intestinal Mucosa/*pathology;
Male;
Middle Aged;
Paraproteinemias/*diagnosis/pathology;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2012;27(2):207-210
- CountryRepublic of Korea
- Language:English
-
Abstract:
Light chain deposition disease (LCDD) is a rare disorder associated with a clonal proliferation of plasma cells, which synthesize abnormal monoclonal immunoglobulin light chains. LCDD is characterized by systemic deposition of light chains in various organs, with the kidneys being most commonly affected. There have been few reports of isolated LCDD. We report a rare case of LCDD limited to a duodenal polyp. A 63-yr-old man visited our hospital for health screening without symptoms in 2009. On gastrofiberscopy, a duodenal polyp was observed. The biopsy showed diffuse infiltration by atypical plasma cells, which were positive for kappa-type light chains by immunohistochemistry. While the patient refused further management, we could find no evidence of recurrence until 2 yr after the initial diagnosis. It has been reported that isolated LCDD has relatively good prognosis compared to systemic LCDD. However, treatment for this disease has not been established yet.
