Genotoxicity research thought and method on traditional Chinese medicine.
- Author:
Jia-yin HAN
;
Yan YI
;
Ai-hua LIANG
;
Yu-shi ZHANG
;
Chun-ying LI
;
Yong ZHAO
;
Lian-mei WANG
;
Gui-qin LI
- Publication Type:Journal Article
- MeSH:
Animals;
Biomedical Research;
Humans;
Medicine, Chinese Traditional;
adverse effects;
Mutagenicity Tests;
methods
- From:
China Journal of Chinese Materia Medica
2015;40(14):2696-2700
- CountryChina
- Language:Chinese
-
Abstract:
Genotoxicity research takes an important place in traditional Chinese medicine safety evaluation. Genotoxicity test on traditional Chinese medicine has been paid great attention since 1970s. Currently, the most developed genotoxicity test methods included: bacterial reverse mutation test and mouse lymphoma assay which are used to detect relevant genetic changes, micronucleus test and chromosomal analysis which are used to measure chromosomal aberration, and single cell electrophoresis assay which is used to test DNA damage. This article reviews research progress on genotoxicity of traditional Chinese medicine, evaluation methods of genotoxicity, the problems and solutions on genotoxicity evaluation of traditional Chinese medicine, and new technique used in genotoxicity test.
