Genetic polymorphism of FMO3 and its role in drug metabolism and toxicity.
- Author:
Zheng GONG
;
Qi WANG
- Publication Type:Journal Article
- MeSH:
Drug-Related Side Effects and Adverse Reactions;
Humans;
Oxygenases;
genetics;
Polymorphism, Genetic
- From:
China Journal of Chinese Materia Medica
2015;40(14):2701-2705
- CountryChina
- Language:Chinese
-
Abstract:
The flavin-containing monooxygenase 3 (FMO3) is an important hepatic microsomal enzyme. Numerous mutations of FMO3 gene have been reported, and polymorphic varients of the gene have been identified. Several studies indicated that variability in the expression of FMO3 involved in some nitrogen, or sulfur-containing durg metabolism. This review summarizes the genetic polymorphism of FMO3 and its role in drug metabolism and toxicity.
