Influence of solvent and drug preparation time on Shuanghuanglian injections induce pseudo-allergic reaction.
- Author:
Yan YI
;
Ai-hua LIANG
;
Chun-ying LI
;
Yu-shi ZHANG
;
Yong ZHAO
;
Jia-yin HAN
;
Yu-ting LU
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Compounding;
Drug Hypersensitivity;
etiology;
Drugs, Chinese Herbal;
adverse effects;
Injections;
Male;
Mice;
Mice, Inbred ICR;
Solvents;
Time Factors
- From:
China Journal of Chinese Materia Medica
2015;40(14):2723-2726
- CountryChina
- Language:Chinese
-
Abstract:
Choosing the right solvent and timely use is the basis of rational drug use and the most direct and efficient way to improve the safety of traditional Chinese medicine injections. This study aimed to evaluate the influence of solvent and drug preparation time on Shuanghuanglian injection inducing pseudo-allergic reactions with mouse mode. The two tests were carried out: (1) Comparative experiment between different solvent: Shuanghuanglian injection preparation to the appropriate concentration with 0.9% sodium chloride injection and 5% dextrose injection, mixed with Evans blue, at one time intravenous injected into mice, 30 minutes later, the mouse ears vascular permeability were observed and compared. (2) Comparative experiment among different preparation time: placed 10 min, 2.5 h, 6 h and 24 h after Shuanghuanglian injection were prepared and then to detect the pseudo-allergic reactions in mice using the same methods as in (1). The results showed that there was no significant difference in the pseudo-allergic reactions in mice which induced by the same dose of Shuanghuanglian injection, respectively with 0.9% sodium chloride injection and 5% dextrose injection preparation, and with the extension of preparation time, the degree of pseudo-allergic reactions of Shuanghuanglian injection was gradually severe.
