Severe Osteomyelitis as a Complication of Tokyo-172 BCG Vaccination.
10.3346/jkms.2012.27.2.221
- Author:
Hyo Jin KWON
1
;
Bo Hyun CHUNG
;
Byung Min CHOI
;
Kyung Un PARK
;
Yun Kyung KIM
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Osteomyelitis;
Complication;
Bacilli Calmette-Guerin Vaccination
- MeSH:
Antitubercular Agents/therapeutic use;
BCG Vaccine/*adverse effects;
DNA, Bacterial/genetics;
Female;
Humans;
Infant;
Magnetic Resonance Imaging;
Multiplex Polymerase Chain Reaction;
Mycobacterium bovis/genetics/*isolation & purification;
Osteomyelitis/drug therapy/*etiology/*microbiology/surgery
- From:Journal of Korean Medical Science
2012;27(2):221-224
- CountryRepublic of Korea
- Language:English
-
Abstract:
The bacilli Calmette-Guerin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.
