Real-time detection of quality of Chinese materia medica: strategy of NIR model evaluation.
- Author:
Zhi-sheng WU
;
Xin-yuan SHI
;
Bing XU
;
Xing-xing DAI
;
Yan-jiang QIAO
- Publication Type:Journal Article
- MeSH:
Materia Medica;
standards;
Medicine, Chinese Traditional;
standards;
Spectroscopy, Near-Infrared;
methods
- From:
China Journal of Chinese Materia Medica
2015;40(14):2774-2781
- CountryChina
- Language:Chinese
-
Abstract:
The definition of critical quality attributes of Chinese materia medica ( CMM) was put forward based on the top-level design concept. Nowadays, coupled with the development of rapid analytical science, rapid assessment of critical quality attributes of CMM was firstly carried out, which was the secondary discipline branch of CMM. Taking near infrared (NIR) spectroscopy as an example, which is a rapid analytical technology in pharmaceutical process over the past decade, systematic review is the chemometric parameters in NIR model evaluation. According to the characteristics of complexity of CMM and trace components analysis, a multi-source information fusion strategy of NIR model was developed for assessment of critical quality attributes of CMM. The strategy has provided guideline for NIR reliable analysis in critical quality attributes of CMM.
