EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer.
10.3346/jkms.2012.27.2.228
- Author:
Guang JIN
1
;
Hyo Sung JEON
;
Eung Bae LEE
;
Hyo Gyoung KANG
;
Seung Soo YOO
;
Shin Yup LEE
;
Jae Hee LEE
;
Sung Ick CHA
;
Tae In PARK
;
Chang Ho KIM
;
Sang Hoon JHEON
;
Jae Yong PARK
Author Information
1. Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
ALK;
EML4;
Carcinoma;
Non-Small-Cell Lung
- MeSH:
Adenocarcinoma/diagnosis/genetics;
Aged;
Asian Continental Ancestry Group/*genetics;
Base Sequence;
Carcinoma, Non-Small-Cell Lung/diagnosis/*genetics;
Exons;
Female;
Humans;
Introns;
Lung Neoplasms/diagnosis/*genetics;
Male;
Middle Aged;
Oncogene Proteins, Fusion/chemistry/*genetics;
Republic of Korea;
Sequence Analysis, RNA;
Smoking
- From:Journal of Korean Medical Science
2012;27(2):228-230
- CountryRepublic of Korea
- Language:English
-
Abstract:
A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.
