Selection of donor in mismatched hematopoietic stem cell transplantation by CREG, residue match and HLA three-dimensional structure.
- Author:
Hong-Xing HAN
1
;
Fan-Hua KONG
;
Yong-Zhi XI
;
Yu-Ying SUN
;
Li JIN
;
Nan LIU
;
Si-Qi GUO
Author Information
1. Department of Immunology of the Affiliated Hospital of Academy Military Medical Sciences, Laboratory of Immunoassay of National Center of Biomedical Analysis, Beijing 100850, China.
- Publication Type:Journal Article
- MeSH:
Cross Reactions;
HLA Antigens;
immunology;
Hematopoietic Stem Cell Transplantation;
Histocompatibility Testing;
Humans;
Tissue Donors
- From:
Journal of Experimental Hematology
2002;10(6):553-556
- CountryChina
- Language:Chinese
-
Abstract:
After search at hematopoietic stem cell banks for transplant donors, there may be several donors matched with given standards. To determine the most appropriate donor for a specific patient, the potential donors were analyzed and compared by three methods. The first is cross-reactive group (CREG) antigens, which defined as the public antigens that shared specific serological reaction patterns. The second is residue match theory, which concerned the three residues oriented upward toward the T-cell receptor. The third is comparing HLA three-dimensional structure models. The results of the three methods were not completely accorded in our case. However, some less matched donors could be excluded from the candidates and the range of selection was further reduced. It is concluded that combined application of three methods would contribute in selecting donor for hematopoietic stem cell transplantation in clinics.
