Role of interleukin-18 in pathogenesis of acute graft-versus-host disease.
- Author:
Xiao-Ping JU
1
;
Jian-Min WANG
;
Jun HOU
;
Cao-Bo FENG
;
Shu-Peng TONG
;
Wei-Ping ZHANG
Author Information
1. Department of Hematology, The Affiliated Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Adolescent;
Adult;
Child;
Graft vs Host Disease;
etiology;
Hematopoiesis;
Humans;
Infection;
etiology;
Interleukin-18;
physiology;
Leukemia;
therapy;
Peripheral Blood Stem Cell Transplantation;
adverse effects
- From:
Journal of Experimental Hematology
2002;10(5):452-454
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship between interleukin-18 (IL-18) and human acute graft-versus-host disease (aGVHD), 26 patients undergoing allogeneic peripheral blood stem cell transplantation (allo-PBSCT) were included in this study. IL-18 secreted by peripheral blood mononuclear cells (MNCs) was measured by enzyme-linked immunosorbent assay (ELISA) before transplantation and during aGVHD. The results showed that grade I GVHD and grades III-IV GVHD developed in 10 and 5 cases, respectively. The levels in the supernatants of MNCs from patients with aGVHD were significantly higher than those in the cases without aGVHD. The levels of IL-18 were correlated with the severity of aGVHD. It is concluded that IL-18 plays an important role in the development of aGVHD.
