Analysis of serologic typing error for HLA-A and HLA-B in Chinese.
- Author:
Yu-Dong DAI
1
;
Qi-Jun SUN
;
Yi-Hong ZHANG
;
Hong YUAN
;
Bo MENG
Author Information
1. Nanjing Red Cross Blood Center, Nanjing 210008, China.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
China;
HLA-A Antigens;
classification;
genetics;
HLA-B Antigens;
classification;
genetics;
Humans;
Serotyping
- From:
Journal of Experimental Hematology
2002;10(5):455-457
- CountryChina
- Language:Chinese
-
Abstract:
Serological mistypings of HLA-A and HLA-B in 27 cases were analyzed. The results showed that for HLA-A and HLA-B typing, the rates of incorrect antigen assignments were significantly higher than rates of antigen misses (P < 0.05), but there was no significant difference between HLA-A and HLA-B typings. The frequencies of miss-assigned HLA-A and HLA-B specificities were A1 (66.7%), A3 (50.0%), A11 (13.5%), A9 (11.8%), A19 (7.1%), and B16 (50.0%), B48 (43.9%), B15 (16.7%), B40 (11.1%), B13 (10.0%) and B17 (9.1%). In conclusion, the serologic and DNA-based typing techniques should be reciprocally complementary in HLA-A and HLA-B typing.
