Determination of serum granulocyte colony-stimulating factor level in patients with chronic idiopathic neutropenia and its significance.
- Author:
Chun-Sen WANG
1
;
Wei DONG
;
Jin-Lin ZHANG
;
Xiao-Dong WANG
;
Yi-Ping TANG
;
Biao ZHU
;
Chun-Qian WAN
;
Mao-Zhou GAN
Author Information
1. Department of Hematology, Sichuan Provincial People's Hospital, Chengdu 610072, China. wangchunsen@163.net
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Chronic Disease;
Enzyme-Linked Immunosorbent Assay;
Female;
Granulocyte Colony-Stimulating Factor;
blood;
Humans;
Male;
Middle Aged;
Neutropenia;
blood
- From:
Journal of Experimental Hematology
2002;10(4):373-374
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the serum granulocyte colony-stimulating factor (G-CSF) level in patients with chronic idiopathic neutropenia (CIN) and analyze its clinical significance. By the use of G-CSF-specific enzyme-linked immunosorbent assay (ELISA), the serum levels of G-CSF were determined in 40 cases with chronic CIN, 40 cases with systemic lupus erythematosus (SLE) complicated neutropenia and 40 healthy volunteer (normal control). Results showed that serum G-CSF was positive in 11 normal controls and in 10 cases with SLE, and the G-CSF levels were (27.34 +/- 8.00) ng/L and (26.76 +/- 7.26) ng/L, respectively. Serum G-CSF in 27 cases with CIN was positive, the level was (134.04 +/- 89.29) ng/L, which was higher than that in the normal controls and the cases with SLE (P < 0.01). It was concluded that an obstacle to utilization of G-CSF could be existed in the patients with CIN.
