Immunophenotypic characteristics of multiple myeloma cells.
- Author:
Jin-Lan LI
1
;
Yan-Rong LIU
;
Yan CHANG
;
Jia-Yu FU
;
Shan-Shan CHEN
Author Information
1. Institute of Hematology, Peking University, Beijing 100044, China.
- Publication Type:Journal Article
- MeSH:
ADP-ribosyl Cyclase;
immunology;
ADP-ribosyl Cyclase 1;
Adult;
Aged;
Antigens, CD;
immunology;
Antigens, CD19;
immunology;
Antigens, CD20;
immunology;
Bone Marrow Cells;
immunology;
CD56 Antigen;
immunology;
Female;
Flow Cytometry;
Humans;
Immunophenotyping;
Leukocyte Common Antigens;
immunology;
Male;
Membrane Glycoproteins;
Middle Aged;
Multiple Myeloma;
immunology
- From:
Journal of Experimental Hematology
2002;10(3):226-228
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the immunophenotypic characteristics of multiple myeloma (MM) cells, 20 bone marrow samples from patients with multiple myeloma were analyzed by flow cytometry with three-color direct immunofluorescence staining. Results showed that all of myeloma cells expressed bright CD38, dim or negative CD45 and negative CD19. Most of the cells were CD56(+) and a small portions were ckappa(+) or clambda(+), or CD20(+). The phenotypes of normal plasmocyte, CD19(+) and CD56(-), except CD56(-) in one-third samples, were not appeared in all detected samples. It was concluded that the surface marker analysis of myeloma cells is a useful tool for diagnosis and further evaluating prognosis of multiple myeloma.
