OBJECTIVETo assess the anti-inflammatory effect of Aike Mixture (AKM) on rats with nonbacterial prostatitis (NBP).

METHODSRat model of NBP was established by injection of Xiaozhiling Injection. The experimental rats were randomized into 7 groups: the three AKM groups (A1, A2 and A3), treated with high, middle and low dose of AKM respectively, the 2 positive control groups (C1 and C2), treated by Bazheng Mixture (BZM) and Qianliexian Decoction (QLXD) respectively, the model control group (Cm) and the sham-operative control group (Cso). The pathological changes in rats' prostate were observed by light microscope and transmission electron microscope.

RESULTSSignificant differences in the number and structure of acini, mesenchyma, as well as the degrees of anti-fibroplasia and inflammatory cell infiltration were shown between the treated groups (A1, A2, A3, C1, C1, C2) and the untreated groups (Cm, Cso), with statistical significance (P < 0.05 or P < 0.01). However, the anti-fibroplasia and anti-inflammatory effects in A1 were better than that in the two positive control groups significantly (P < 0.05 or P < 0.01).

CONCLUSIONSAKM is a new TCM drug functioned for dispersing Gan-qi in treating NBP. It shows a better efficacy than that of BZM and QLXD, the two Chinese herbal medicines for clearing heat with remove dampness and activating blood circulation to remove stasis, respectively. Aike Mixture; prostatitis; pathological observation