Yin-yang relationship between oncogene and antioncogene.
- Author:
Yong-sheng JIA
1
;
Jian-quan ZHENG
Author Information
1. Beijing Institute of Pharmacology and Toxicology.
- Publication Type:Journal Article
- MeSH:
Genes, Tumor Suppressor;
Humans;
Medicine, Chinese Traditional;
Neoplasms;
genetics;
Oncogenes;
genetics;
Proto-Oncogene Proteins c-myc;
metabolism;
Tumor Suppressor Protein p53;
metabolism;
Yin-Yang
- From:
Chinese Journal of Integrated Traditional and Western Medicine
2009;29(1):72-75
- CountryChina
- Language:Chinese
-
Abstract:
Oncogene and antioncogene play contrary effects on the cell growth and proliferation controlling process, and cancer occurs when the presence of imbalance expression between them. That means there is yin-yang relationship between oncogene (yang) and antioncogene (yin), and also inside both of them. Taking the oncogene myc and antioncogene p53 for example, the yin gene p53 acts, in the yin side, to promote cell apoptosis and inhibit cell growth, while in the yang side, it facilitates for repairing the injured DNA to keep cell survival; the yang gene myc, promoting cell growth and proliferation in the yang side and inducing cell apoptosis in the yin side. To elucidate the yin-yang reactions between oncogene and antioncogene would be of important significance in the all-round and profound research of cancer.
