Positron emission tomography with L-S-methyl-11C-methioine and its biodistribution.
- Author:
Li-guang CHEN
1
;
Mei-juan ZHOU
;
An-wu TAN
;
Shu-xia WANG
;
Shan-zhen HE
;
Zhen-hua DING
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Animals; Brain; diagnostic imaging; metabolism; pathology; Brain Neoplasms; diagnosis; diagnostic imaging; metabolism; Carbon Radioisotopes; Female; Glioma; diagnosis; diagnostic imaging; metabolism; Humans; Injections, Intravenous; Male; Middle Aged; Positron-Emission Tomography; methods; Radiopharmaceuticals; administration & dosage; pharmacokinetics; Rats; Rats, Wistar; Sensitivity and Specificity; Tissue Distribution; Vitamin U; administration & dosage; pharmacokinetics
- From: Journal of Southern Medical University 2007;27(6):834-835
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the biodistribution of L-[S-methyl-(11)C]-methioine ((11)C-MET) and explore its clinical application in positron emission tomography (PET) for brain tumor detection.
METHODSTwenty-four Wistar rats and divided into 6 equal groups and injected with (11)C-MET through the tail vein and killed by decollation at 5, 10, 20, 30 and 40 min after injection, respectively. The liver, brain, blood, heart, lung, kidney, and spleen were harvested to measure the radioactivity and calculate the biodistribution of (11)C-MET. PET imaging with (11)C-MET was performed in 6 normal volunteers and 30 patients with pathologically confirmed brain gliomas.
RESULTS AND CONCLUSION(11)C-MET showed high blood uptake and a long retention in the tumor mass, therefore can be a valuable tracer for PET imaging of brain tumor and the hypophysis.
