Effect of saikosaponin alpha on experimental epilepsy in rats.
- Author:
Chang-zheng LI
1
;
Wei XIE
;
Yong BAO
;
Ye ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents, Non-Steroidal; pharmacology; Anticonvulsants; pharmacology; Epilepsy; chemically induced; prevention & control; Female; Male; Oleanolic Acid; analogs & derivatives; pharmacology; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Saponins; pharmacology; Time Factors
- From: Journal of Southern Medical University 2007;27(6):839-840
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of saikosaponin alpha (SSalpha) on experimental epilepsy in rats.
METHODSAcute epileptic seizure was induced by pentylenetetrazole (PTZ) in rats, and the seizure incubation period and the number of rats with tetanic convulsion were recorded to study the antiepileptic effect of SSalpha.
RESULTSAfter treatment with SSalpha, the incubation period of PTZ-induced seizure was significantly prolonged (P<0.01), and the rate of tetanic convulsion was significantly reduced (P<0.05).
CONCLUSIONSSalpha can inhibit epileptic seizure induced by PTZ.
