Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension.
- Author:
Xu DONG
1
;
Gang WANG
;
Huai-liang WANG
;
Xin-hua ZHANG
;
Zhi-hong ZONG
;
Jun XING
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chronic Disease; Hypertension, Pulmonary; chemically induced; enzymology; Inflammation; chemically induced; enzymology; Male; Monocrotaline; Protein Kinase C; metabolism; Pulmonary Artery; enzymology; Rats; Rats, Wistar
- From: Journal of Southern Medical University 2007;27(6):875-877
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the changes in pulmonary artery protein kinase C (PKC) activity in rats with chronic inflammatory pulmonary hypertension (PHT).
METHODSChronic inflammatory PHT was induced in rats with monocrotaline. The PKC activities in the rat pulmonary arteries were measured by radioactive assay during the development of PHT.
RESULTSWith the development of chronic inflammatory PHT, the total and cytosolic fractions of PKC activity in PHT rat pulmonary arteries increased initially with subsequent decrease (Plt;0.05), but the membranous fraction of PKC activity and the membrane-to-cytosol PKC activity ratio increased continuously (P<0.05).
CONCLUSIONThe up-regulation of PKC activity and the translocation of PKC might be associated with the development of chronic inflammatory PHT in rats.
