Relationship between hepatitis B virus genotypes and liver fibrosis.
- Author:
Yue-hua HUANG
1
;
Zhi-jian YU
;
Cheng WANG
;
Bin ZHOU
;
Jin-lin HOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Genotype; Hepatitis B virus; genetics; physiology; Hepatitis B, Chronic; blood; virology; Humans; Liver Cirrhosis; blood; virology; Male; Middle Aged
- From: Journal of Southern Medical University 2007;27(7):1012-1014
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between hepatitis B virus (HBV) genotypes and liver fibrosis.
METHODSPolymerase chain reaction-restriction fragment length polymorphism method was employed to determine HBV genotypes in 298 HBV-related liver disease patients, including 73 with hepatocellular carcinoma, 53 with liver cirrhosis, 91 with chronic hepatitis B and 82 asymptomatic HBV carriers to analyze the relationship of HBV genotypes with serum fibrous indices and serum albumin and globulin (A/G) ratio.
RESULTSB and C genotypes were dominant in patients with HBV-related hepatic diseases in Guangdong province. The levels of serum fibrous indices were significantly higher in patients with genotype C than in those with genotype B, and the former patients also had lower A/G ratio.
CONCLUSIONPatients with HBV genotype C may sustain more serious liver injury.
