Levels of C-reactive protein and antibodies against oxidized low-density lipoprotein in patients with different types of coronary heart disease.
- Author:
Li-qin MA
1
;
Hua ZHENG
;
Sai-zhu WU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Antibodies; blood; immunology; Biomarkers; blood; metabolism; C-Reactive Protein; metabolism; Case-Control Studies; Coronary Disease; blood; complications; metabolism; pathology; Female; Humans; Lipoproteins, LDL; immunology; Male; Middle Aged
- From: Journal of Southern Medical University 2007;27(7):1068-1070
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation of the levels of C-reactive protein (CRP) and antibodies against oxidized low-density lipoprotein (anti-oxLDL) to with acute coronary syndrome (ACS).
METHODSThe levels of CRP, anti-oxLDL and anti-LDL were measured and compared in 96 subjects including 26 with acute myocardial infarction (AMI), 29 with unstable angina pectoris (UAP), 20 with stable angina pectoris (SAP) and 21 control subjects to evaluate the relationship between CRP and anti-oxLDL.
RESULTSBoth CRP and anti-oxLDL levels in patients with ACS, including AMI and UAP, were significantly higher than those in SAP patients and the control subjects (P<0.05), but the level of anti-LDL showed no significant difference between the groups (P>0.05). There was significant positive correlation between the levels of CRP and anti-oxLDL (P<0.001).
CONCLUSIONThe specific immune response to oxLDL may play an important role in the instability of plaque and the occurrence of ACS, and anti-oxLDL level may serve as an important specific marker for the instability of plaque.
