Effect of p53 gene knockout on cell migration.
- Author:
Xiao-Wei GONG
1
;
Jie WEI
;
Yu-Sheng LI
;
Wei-Wei CHENG
;
Xu WANG
;
Peng DENG
;
Yong JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Line; Cell Movement; genetics; Gene Expression Regulation; Gene Knockout Techniques; Mice; Pseudopodia; genetics; metabolism; Serum; metabolism; Tumor Suppressor Protein p53; deficiency; genetics; metabolism
- From: Journal of Southern Medical University 2007;27(8):1132-1135
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of p53 gene in serum-induced cell migration.
METHODSThe effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system.
RESULTSp53(+/+) cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation.
CONCLUSIONp53 plays a role in serum-induced cell migration.
