Analgesic effect of interleukin-2 in mouse models of spared nerve injury.
- Author:
Shan LIU
1
;
Lin SHI
;
Jun-Yang WANG
;
Gui-Xiang FAN
;
Yu-Kang YUAN
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics; administration & dosage; antagonists & inhibitors; pharmacology; therapeutic use; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hyperalgesia; complications; drug therapy; Interleukin-2; administration & dosage; antagonists & inhibitors; pharmacology; therapeutic use; Male; Mice; Mice, Inbred BALB C; Naloxone; pharmacology; Trauma, Nervous System; complications; drug therapy
- From: Journal of Southern Medical University 2007;27(8):1180-1182
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).
METHODIL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.
RESULTSIL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively. The effect of IL-2 could be significantly antagonized by naloxone.
CONCLUSIONSIL-2 has long-lasting analgesic effects in mouse models of SNI model, showing a double-peak pattern of its action. The analgesic effect of IL-2 is probably mediated by opiate receptor.
