Clinicopathological implications of positive CK7 expression in colorectal carcinoma.
- Author:
Li YU
1
;
Yan-Qing DING
;
Sha XIAO
;
Fei-Ju LAI
;
Xian LU
Author Information
- Publication Type:Journal Article
- MeSH: Colorectal Neoplasms; genetics; metabolism; pathology; Cytoplasm; metabolism; pathology; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Intestinal Mucosa; metabolism; pathology; Keratin-7; metabolism; Male; Middle Aged
- From: Journal of Southern Medical University 2007;27(8):1190-1192
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathological significance of positive CK7 expression in human colorectal carcinoma (HCC).
METHODSImmunohistochemistry was used to detect CK7 and CK20 protein expressions in 68 cases of HCC, 20 cases of canalicular adenoma (CA), 5 cases of serrated adenoma (SA) and 20 cases of hyperplastic polyps (HP).
RESULTSThe positivity rate of CK20 expression was 89.7% in HCC, and 100% in CA, SA and HP. In HCC, the expression rate of CK7 (39.7%) was not correlated with Dukes' classification, differentiation and tumor location. CK7 positivity rate in colon cancer was 35.7% (15/52) and 42.3% (11/26) in rectal cancer. CK7 expression was negative in CA. CK7 positivity rate in SA was 49% and 30% in HP.
CONCLUSIONCK7 is a possible marker for colorectal carcinogenesis from HP to SA, and ultimately to HCC, and examination of the colorectal polypoid lesions for CK7 expression can be significant for estimating the colorectal polypous cancerization.
