- Author:
Michael LIANG
1
;
Takashi KAJIYA
1
;
Mark Y CHAN
1
;
Edgar TAY
1
;
Chi-Hang LEE
1
;
Arthur Mark RICHARDS
1
;
Adrian F LOW
1
;
Huay Cheem TAN
1
Author Information
- Publication Type:Journal Article
- Keywords: acute myocardial infarction; atherosclerosis; coronary artery disease; lesion assessment; percutaneous coronary intervention
- MeSH: Adult; Aged; Angioplasty; Angioplasty, Balloon, Coronary; Constriction, Pathologic; Coronary Angiography; Coronary Vessels; surgery; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Plaque, Atherosclerotic; complications; Reference Values; Retrospective Studies; Rupture; complications; ST Elevation Myocardial Infarction; etiology; surgery; Sex Factors; Thrombectomy; methods
- From:Singapore medical journal 2015;56(6):334-338
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONConventional knowledge holds that the majority of ruptured atherosclerotic plaques causing ST-segment elevation myocardial infarction (STEMI) are found in moderate stenoses that produce < 50% loss of arterial diameter. This study aimed to analyse the culprit lesions in patients who presented with STEMI and underwent primary percutaneous coronary intervention (PPCI) at our institution.
METHODSPatients who underwent PPCI between June 2008 and August 2010 at our institution were included in the analysis. Quantitative coronary angiography was performed for the culprit lesions immediately after antegrade flow was restored by thrombectomy, low-profile balloon predilatation or guidewire crossing.
RESULTSA total of 1,021 patients were included in the study. The mean age was 57 ± 12 years and 85.2% were male. Lesion measurement was done after coronary flow was restored by thrombectomy (73.1%), balloon dilatation (24.1%) and following guidewire passage across the lesion (2.8%). Mean minimal luminal diameter was 1.1 ± 0.5 mm, mean reference vessel diameter was 2.8 ± 0.6 mm, mean diameter stenosis was 61 ± 16% and mean lesion length was 16 ± 6 mm. Most (80.2%) of the culprit lesions had diameter stenoses > 50% (p < 0.01). Although balloon angioplasty was performed in 24.1% of the patients, the majority (64.2%) still had diameter stenoses > 50%. High-grade stenoses (> 50%) were more frequently observed in male patients (p = 0.04).
CONCLUSIONContrary to the existing paradigm, we found that most of the patients with STEMI in our institution had culprit lesions with diameter stenosis > 50%.