HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis.
- Author:
Dantong ZHAO
1
;
Huiyu LIAO
;
Xin ZHANG
;
Yanmin LIU
;
Haiping ZHANG
;
Chunyang HUANG
;
Limei SUN
;
Huiping YAN
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; China; Gene Frequency; Haplotypes; Histocompatibility Antigens Class I; Humans; Liver Cirrhosis, Biliary; Polymerase Chain Reaction
- From: Chinese Journal of Hepatology 2014;22(12):904-909
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis (PBC).
METHODSSequencing based typing-polymerase chain reaction (SBT-PCR) was used to investigate the HLA class I alleles of 146 PBC patients and 500 normal controls in northern China. The frequencies of alleles and haplotypes were calculated and compared for the two groups. The chi-square test and Fisher's exact test were used for statistical analyses.
RESULTSThere were 26, 51 and 21 alleles identified at the HLA-A, B and C loci respectively, and the frequencies of these alleles were not significantly different between the PBC and normal control groups.However, the frequencies of A *11:01-B*40:06 and A*02:01-B*l5:01 haplotypes were significantly higher in the PBC group than in the normal control group (7.53% vs. 1.40%, P<0.01, OR=5.38; 6.85% vs. 2.00%, P=0.003, OR=3.425).
CONCLUSIONThis study established the role of HLA class I haplotypes in determining PBC susceptibility in a Chinese population.
