KLF6mRNA expression in primary hepatocellular carcinoma.
- Author:
Shaoping WANG
1
;
Xiaoping CHEN
;
Wanguang ZHANG
;
Fazu QIU
Author Information
1. Hepatic Surgery Center Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Hepatocellular;
metabolism;
Humans;
Kruppel-Like Factor 6;
Kruppel-Like Transcription Factors;
biosynthesis;
genetics;
Liver;
metabolism;
Liver Neoplasms;
metabolism;
Proto-Oncogene Proteins;
biosynthesis;
genetics;
RNA, Messenger;
biosynthesis;
genetics;
Reverse Transcriptase Polymerase Chain Reaction
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(6):585-587
- CountryChina
- Language:English
-
Abstract:
To investigate the expression of KLF6mRNA in primary hepatocellular carcinoma (HCC), nomal liver tissues and the tissues adjacent to the cancers, reverse-transcription polymerase chain reaction (RT-PCR) was employed to investigate the expression of the KLF6 gene in HCC, the corresponding adjacent non-cancerous tissues and normal liver tissue. Our results showed that an amplified fragment of 427 bp DNA was detected in 18 of 19 (94.7%) adjacent non-cancerous tissues and normal liver tissue, and in 12 (85.7%) of 14 HCC. There were no significant differences in the levels of KLF6 mRNA between normal liver and liver tumors (P>0.05). It is concluded that KLF6 mRNA is generally expressed in HCC.
