Expression of hypoxia inducible factor-1alpha and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma.
- Author:
Linlin YU
1
;
Yang LIU
;
Yonghua CUI
Author Information
1. Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Apoptosis;
physiology;
Carcinoma, Squamous Cell;
metabolism;
secondary;
Cell Proliferation;
Female;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit;
biosynthesis;
genetics;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymph Nodes;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Proliferating Cell Nuclear Antigen;
biosynthesis;
genetics;
Tumor Cells, Cultured
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(6):636-638
- CountryChina
- Language:English
-
Abstract:
To investigate the expression of hypoxia inducible factor-1 alpha (HIF-1alpha) and its relationship to apoptosis and proliferation in laryngeal squamous cell carcinoma (LSCC), immunohistochemical method was used to detect the expression of HIF-1alpha and PCNA. Tunnel technique was used to detect in situ cell apoptosis in LSCC. Our results showed that the expression of HIF-1alpha was related to the clinical stages of cancer and lymph node metastasis (P<0.05). The relationship between HIF-1alpha and PCNA was statistically significant (P<0.05) and no relationship was found between HIF-1alpha and apoptosis (P>0.05) It is concluded that HIF-1alpha plays a role in the carcinogenesis of laryngeal carcinoma and is correlated with proliferation, but bears no relationship with the apoptosis of tumor cells in LSCC.
