Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1in Human Meningiomas
- Author:
Wei YI
1
;
Jian CHEN
;
H.Golwa FILIMON
;
Delin XUE
Author Information
1. Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
- Keywords:
meningiomas;
basic fibroblast growth factor;
fibroblast growth factor receptor-l;
microvascular density;
immunohistochemistry
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2005;25(1):75-77
- CountryChina
- Language:Chinese
-
Abstract:
The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1.The tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.
