Changes of oxidative stress in peripheral serum of patients with allergic rhinitis
10.3760/cma.j.issn.1673-0860.2010.06.004
- VernacularTitle:变应性鼻炎患者血清氧化应激状态研究
- Author:
Jian JIAO
1
;
Wei ZHANG
;
Na MENG
;
Hong WANG
;
Luo ZHANG
Author Information
1. 首都医科大学附属北京同仁医院
- Keywords:
Oxidative stress;
Superoxide dismutase;
Rhinitis,allergic;
Nitric oxide;
Nitric oxide synthase
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2010;45(6):455-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the changes of oxidative stress biomarkers in peripheral serum of patients with allergic rhinitis (AR) , so as to investigate the role of oxidative stress in pathogenesis of AR. Methods The levels of serum nitric oxide (NO), malondidehyde (MDA) , as well as the activities of serum nitric oxide synthase (NOS), antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in 48 AR patients and 23 healthy controls. Statistical analysis was performed using a SPSS 13. 0 software. Results The level of serum NO in AR group [ (97. 92 ±73.42) μmol/L] was higher than that in healthy control group [ (64. 04 ± 29. 54) μmol/L] , the diference was significant (t = -0. 281, P <0.05). The ratio of inducible NOS (iNOS) to total NOS (TNOS) in AR group (0.51 ±0. 11) was higher than that in healthy control group (0.45 ±0. 15), the diference was significant (t = - 2.061, P < 0.05 ) . The activity of serum GSH-Px in AR group [ (258. 24 ±45.25) U/(ml ·min) ] was higher than that in healthy control group(215. 11 ±47.62) U/( ml ·min) ] , the diference was significant (t = - 2. 235, P < 0. 05 ). Although activity of SOD, concentration of MDA in AR group had a tendency to increase and decrease, respectively, no significant statistical difference was found as compared to the control group(P >0. 05). Conclusion Oxidative stress is involved in the pathophysiology of AR, however, iNOS-NO pathway may play a more important role in AR pathogenesis.
