DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis
10.3760/cma.j.issn.1673-0860.2010.06.012
- VernacularTitle:DJ-1蛋白在喉鳞状细胞癌中的表达及其与复发和转移的关系
- Author:
Xiao-Lin ZHU
1
;
Wei-Ping WEN
;
Wen-Bin LEI
;
Li-Ping CHAI
;
Wei-Jian HOU
;
Yi-Hui WEN
;
Xian-Ren WANG
Author Information
1. 中山大学附属第一医院,耳鼻咽喉科医院
- Keywords:
Laryngeal neoplasms;
Carcinoma,squamous cell;
Oncogene proteins;
Intracellular signaling peptides and proteins;
Immunohistochemistry
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2010;45(6):497-501
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of DJ-1 in laryngeal squamous cell carcinoma (LSCC) and to study the relationship between DJ-1 expression and clinical indexes of LSCC. Methods The expressions of DJ-1 protein in 71 LSCC samples and 9 cases control samples from laryngeal mucosa tissues of non-LSCC patients were detected using streptavidin peroxidase immunohistochemistry stainin and the relationships between DJ-1 protein expression and clinicopathologic characteristics were analyzed. Results ( 1 ) The positive expression rate of DJ-1 protein in LSCC was 85.9% (61/71), which was significantly higher than the rate (55.5% ,5/9) in control laryngeal mucosa tissues (P<0.05). (2) DJ-1 expression was related to tumor recurrence (P <0. 05) ,but not to sex,age,primary cancer position,T stage, clinical stage, lymph node metastasis and tumor differentiation. Tumor recurrence rate (53. 3% ) in the patients with higher expression of DJ-1 protein was higher than the rate ( 26. 8% ) in the patients with lower expression of DJ-1 protein ( X2 = 5. 164, P < 0. 05 ). (3 ) With Kaplan-Meier curves and Cox regression analysis,the cumulative 5-year survival rates were correlated with DJ-1 expression levels in laryngeal cancer tissues or cervical lymph node metastasis (all P < 0. 05 ), but not to sex, age, primary cancer position, T stage, clinical stage and tumor differentiation. Conclusions The expression of DJ-1 protein in LSCC is higher than that in control laryngeal mucous tissues. Overexpression of DJ-1 is associated with poor overall survival in ISCC patients.
