A related heredity epidemiological research on allergic rhinitis and asthma in Nantong region
10.3760/cma.j.issn.1673-0860.2010.06.013
- VernacularTitle:江苏南通地区变应性鼻炎与支气管哮喘患病相关性的遗传流行病学研究
- Author:
Li MA
1
;
Da-Ling CHEN
;
Ru-Xin ZHANG
;
Xiao-Lei WANG
;
Yun-Jian SHI
;
Chao JI
;
Zhi-Jun HUANG
;
Mao-Hua QIAN
;
Gang GAO
;
Yong-Juan HUANG
;
Pei GUAN
Author Information
1. 南通大学第二附属医院
- Keywords:
Rhinitis,allergic;
Asthma;
Epidemiologic factors;
Genetic screening
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2010;45(6):502-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the related impact of genetic factors in the incidence of bronchial asthma ( BA) and allergic rhinitis ( AR) in Nantong region, China. Methods By random sampling method, investigation and research on the incidence of genetic epidemiology were carried out in the population of 95 300 on AR and BA. Results The rate of patients with allergic rhinitis with asthma was 25.92% (296/1142), the rate of asthma patients with allergic rhinitis was 40.49% (296/731). The prevalences of AR complicated with BA were 8.19% (280/3418), 3.08% (154/5002) and 3.16% (85/2687) in the first-, second-and third-degree relatives of the probands respectively, while the prevalences of BA complicated with AR were 15.81% (466/2947), 4.61% (229/4967) and 2.51% (134/5345) in the first-,second- and third-degree relatives of the probands respectively, higher than those in the controls (P < 0. 05). The weighted mean heritability of AR in BA patients was 94. 2% ±1.9%, while the weighted mean heritability of BA in AR patients was 81. 8% ±2. 1% , more than 60% , suggesting that both AR and BA were relevant with genetics. Conclusions The incidence of BA and AR has obvious relevance, supporting the theory that the two diseases are an united airway disease and relevant with polygene heredity.
