Plasma gamma-glutamyl transpeptidase level as a cardiovascular risk factor in elderly patients with hypertension or hypertension with diabetes mellitus.
- Author:
Xue-ying LU
1
;
Zhao-di WANG
;
Yun-mei YANG
;
Zhe-rong XU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Cardiovascular Diseases; etiology; Case-Control Studies; Diabetes Mellitus; enzymology; Female; Humans; Hypertension; complications; enzymology; Male; Middle Aged; Risk Factors; gamma-Glutamyltransferase; blood
- From: Journal of Zhejiang University. Medical sciences 2012;41(2):192-195
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate plasma gamma-glutamyl transpeptidase (γ-GGT) level as a cardiovascular risk factor in elderly patients with hypertension or hypertension with diabetes mellitus.
METHODSForty-nine elderly patients of hypertension and 42 elderly patients of hypertension with diabetes mellitus and 39 healthy elderly subjects were enrolled in the study. The height, weight and blood pressure of patients were measured, serum C reactive protein and other biochemical indicators were detected. The relation between plasma γ-GGT and cardiovascular risk factors in three groups were analyzed.
RESULTSThere was no significant difference in plasma γ-GGT levels among three groups. There was a positive correlation of plasma γ-GGT levels with systolic pressure, pulse pressure, hemoglobin A1c and CRP in control group. While in hypertension with diabetes mellitus group, plasma γ-GGT levels were correlated with systolic pressure, mean arterial pressure, fasting blood sugar and cystatin.
CONCLUSIONPlasma γ-GGT might be a risk factor for cardiovascular diseases, and may be used as a predictive indicator for kidney injury in early patients with hypertension with diabetes mellitus.
