Molecular mechanisms of TRP channels in mechano-sensory transduction.
- Author:
Wen-juan ZOU
1
;
Gui-fang HUANG
;
Li-jun KANG
Author Information
1. Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Neural Conduction;
Sensation;
physiology;
Signal Transduction;
Transient Receptor Potential Channels;
metabolism;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2012;41(2):222-228
- CountryChina
- Language:Chinese
-
Abstract:
Channels from the TRP superfamily have essential roles in a wide variety of sensory transductions, especially in mechano-sensation, such as hearing, touch and mechanical pain. TRP channels are also implicated in major channelopathies, including deafness, chronic pain, autosomal dominant polycystic kidney disease (ADPKD) and ventricular hypertrophy. As the leading candidates for mechano-sensitive channels, some TRP channels appear to be mechano-receptor, which can be activated by mechanical forces directly, such as C. elegans TRPN homolog TRP-4; whereas others may act as signal modulators, receiving and amplifying signals indirectly. This review is to introduce the function of TRPs in mechano-sensory transduction and to discuss the underlying molecular mechanisms.
