Construction of a multiple-scale implant surface with super-hydrophilicity.
- Author:
Qiao-jie LUO
1
;
Xiao-dong LI
;
Ying HUANG
;
Shi-fang ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: 3T3 Cells; Animals; Cell Adhesion; drug effects; Cell Differentiation; drug effects; Cell Proliferation; drug effects; Dental Etching; Dental Implants; Hydrophobic and Hydrophilic Interactions; Mice; Surface Properties; Titanium; chemistry; pharmacology
- From: Journal of Zhejiang University. Medical sciences 2012;41(3):239-244
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo construct a multiple-scale organized implant surface with super-hydrophilicity.
METHODSThe SiC paper polished titanium disc was sandblasted and treated with HF/HNO₃ and HCl/H₂SO₄, then acid-etched with H₂SO₄/H₂O₂. The physicochemical properties of the surfaces were characterized by scanning electron microscope, static state contact angle and X-ray diffraction. MC3T3-E1 cells were used to evaluate the effects of the surface on the cell adhesion, proliferation and differentiation.
RESULTSThe acid-etching process with a mixture of H₂SO₄/H₂O₂ superimposed the nano-scale structure on the micro-scale texture. The multiple-scale implant surface promoted its hydrophilicity and was more favorable to the responses of osteoprogenitor cells, characterized by increased DNA content, enhanced ALP activity and promoted OC production.
CONCLUSIONA multiple-scale implant surface with super-hydrophilicity has been constructed in this study, which facilitates cell proliferation and adhesion.