Serum sCD44v6 and sE-cadherin levels in patients with esophageal squamous cell carcinoma.
- Author:
Ying HE
1
;
Jun ZHANG
;
Shu-kui WANG
;
Wen-bin HUANG
;
Xin-guo CHEN
;
Bang-shun HE
;
You-cai ZHAO
;
Jin-song WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Cadherins; blood; Carcinoma, Squamous Cell; blood; pathology; Case-Control Studies; Esophageal Neoplasms; blood; pathology; Female; Humans; Hyaluronan Receptors; blood; Male; Middle Aged
- From: Journal of Zhejiang University. Medical sciences 2012;41(3):305-309
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the serum levels of sCD44v6 and sE-cadherin (sE-cad) in patients with esophageal squamous cell carcinoma.
METHODSThe serum samples were collected from 65 cases of esophageal squamous cell carcinoma, 32 cases of erosive esophagitis and 35 healthy subjects. Serum sCD44v6 and sE-cad levels were measured by enzyme linked immunosorbent assay (ELISA).
RESULTSThe mean levels of serum sCD44v6 and sE-cad in esophageal squamous cell carcinoma patients were significantly higher than those of erosive esophagitis patients and normal controls (both P<0.05). There was no significant difference in serum sCD44v6 and sE-cad levels between erosive esophagitis patients normal controls (P=0.566 and P=0.708, respectively). Serum sCD44v6 and sE-cad levels of esophageal cancer patients were not correlated with their clinicopathological features. Serum sCD44v6 level is not correlated with sE-cad level in squamous cell carcinoma patients(P=0.651).
CONCLUSIONSerum sCD44v6 and sE-cad might be a potential marker for screening of esophageal squamous cell carcinoma.
