Characteristic of microglial activation of hippocampus in experimental epileptic rats.
- Author:
Hong SUN
1
;
Hai-qin WU
;
Gui-lian ZHANG
;
Shu-qin ZHAN
;
Ru ZHANG
;
Hu-qing WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Proliferation; Disease Models, Animal; Hippocampus; cytology; pathology; Male; Microglia; pathology; Rats; Rats, Sprague-Dawley; Status Epilepticus; pathology
- From: Journal of Zhejiang University. Medical sciences 2012;41(3):310-314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats.
METHODSMorphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats.
RESULTSOX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d.
CONCLUSIONInflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.
