Serum antigens assay combined with chest CT scan in diagnosis of invasive pulmonary aspergillosis.
- Author:
Pan-feng XU
1
;
Jian-ying ZHOU
;
Hua ZHOU
;
Ping SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Female; Humans; Invasive Pulmonary Aspergillosis; blood; diagnosis; diagnostic imaging; Male; Mannans; blood; Middle Aged; Sensitivity and Specificity; Tomography, X-Ray Computed; Young Adult; beta-Glucans; blood
- From: Journal of Zhejiang University. Medical sciences 2012;41(3):332-338
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate serum antigens assay combined with chest CT scan in the diagnosis of patients of invasive pulmonary aspergillosis (IPA) without neutropenia.
METHODSOne hundred and thirteen patients with suspected IPA admitted in Department of Respiratory Medicine, Infectious Diseased, Kidney Disease Centre and ICU were included in the study. Serum levels of 1-3-β-D-glucan (G) antigen and galactomannan antigen (GM) were assayed and chest CT scans were performed in all cases. Clinically invasive pulmonary aspergillosis was defined as proven, probable and possible. Treatment effectiveness was recorded.
RESULTSIn this series 4 proven IPA, 36 probable IPA, 16 possible IPA, and 57 non-aspergillosis infection were diagnosed. GM test was more sensitive than G test. The specificity of two serum test was 84.2% and 87.7%, respectively. The sensitivity of chest CT was 30.0 %. The specificity of GM assay combined with chest CT was 100.0 %, while the sensitivity was 47.5%.
CONCLUSIONThe GM assay combined with chest CT may increase the specificity of diagnosis for IPA patients without neutropenia.
